He was principal viola with the Boston Symphony Orchestra and, later, the Philadelphia Orchestra. He gave the first performance of Walter Piston's Viola Concerto and George Rochberg's Viola Sonata. He recorded for Albany Records, Boston, Decca, RCA and Sony.
He was Professor of Viola at the Curtis Institute, and his students included Cathy Basrak, Roberto Díaz, Richard Fleischman and Stephen Wyrczynski.
Joseph de Pasquale died on 22 June 2015, aged ninety-five.